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Mayo Clinic Proceedings

These lesions are most commonly encountered on the lower extremities or peristomal region, but because this skin condition is pathergic (similar to Behet syndrome), these lesions can occur in any area that is frequently traumatized (Figure 17.1)

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The core premise is metabolic selectivity: it activates the lipolytic machinery of fat tissue without engaging the growth hormone receptor or elevating IGF-1

Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test

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