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Therefore, conducting in-depth investigations into the use of quercetin as a treatment modality for GA represents a valuable avenue of study, with the potential to shed light on its clinical efficacy and mechanistic underpinnings

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617 Exposure of astrocytes to -amyloid down-regulates expression of glutamine synthetase, 618 and in animal models, glutamine synthetase expression is reduced in astrocytes surrounding -amyloid plaques

291,292 When cells accumulate large amounts of misfolded peptides and oxidatively damaged proteins, protein degradation systems are required to degrade them to maintain cellular homeostasis