In a high salt stress experiment in Gracilariopsis lemaneiformis , trehalose-6phosphate phosphatase 1 ( TPS1 ) protein levels were elevated to 2.03fold those of the control plants within 48 h, accompanied by a marked increase in TPS enzymatic activity [89]
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Impaired FAD-dependent enzyme activity is also detrimental to bloodbrain barrier (BBB) integrity, leading to downregulation of tight-junction proteins such as claudin-5 and occluding, increased permeability, and enhanced peripheral immune infiltration
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It did both of these things while crossing the blood-brain barrier and maintaining a plasma half-life exceeding 6 hours, which means sustained brain exposure from a single administration
