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Opioid Receptors: While not a classic opioid, DSIP exhibits agonistic activity on opioid receptors or modulates endogenous opioid peptides (enkephalins/endorphins)

Transitioning off is also commonly discussed, especially for people who worry about rebound inflammation or a sudden return of symptoms when stopping

Peri-lesional injection requires precise anatomical knowledge and a higher technical skill level, and the marginal benefit over subcutaneous delivery is not clearly established

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This comprehensive approach makes GHK-Cu valuable for research applications requiring broad cellular support rather than single-target interventions