Ubiquitinating a protein can signal for its degradation and affect its activity
Mol Metab 60:101489
In the brain, elevated blood pressure results in iron overload, which increases oxidative stress and lipid peroxidation, eventually leading to brain injury (Yang L
Modern studies have reported that Ganoderma polysaccharides, as its core active metabolites, can exert antioxidant and neuroprotective effects by inhibiting mitochondrial oxidative stress ( in vivo experimental study based on rat HH test model has reported that the aqueous extract of Ganoderma lucidum can improve neurotransmitter levels in HH animal models, prevent the surge of glucocorticoids and -synuclein, induce the upregulation of CREB/p-CREB/BDNF expression through ERK1/ERK2 to improve synaptic plasticity, and maintain redox homeostasis, to improve HH-related spatial memory deficits and neuronal damage ( Ganoderma lucidum and its active metabolites, through multi-dimensional regulation of neurotransmitter networks, oxidative stress responses, and synaptic remodeling, may provide a potential intervention strategy for HACE-induced cognitive dysfunction and brain tissue damage
GHK-Cu Dosing and How to Use It Unfortunately there are no known FDA approved dosing guidelines or dosing suggestions
Neither is acceptable
