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37,68 The Siddha system, predominantly practiced in South India, also adheres to a humoral theory, focusing on the equilibrium among three fundamental humors: Vali (air), Azhal (fire), and Iyyam (water)

The ER, which is responsible for essential cellular functions including protein folding and calcium storage/signaling, can experience disturbances in the folding environment, leading to the accumulation of misfolded proteins and subsequent ER stress

Epithalon represents a distinct longevity-research angle from NAD+: where NAD+ concerns cellular energy and sirtuin signaling, Epithalon concerns chromosomal aging and the telomere-maintenance machinery

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