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However, in ME2 homozygously deleted PDAC cell lines, its isoenzyme ME3 plays the compensatory roles for intracellular NADPH homeostasis

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This review does not comprehensively address APAP toxicity in specific vulnerable populations, such as neonates, pediatric patients, pregnant women, or the elderly, who may exhibit distinct pharmacokinetics, pharmacodynamics, and susceptibility to liver injury

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