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(2019) 33:e22267

Notably, during pre-ovulatory luteogenesis, the LH peak not only induces follicular rupture but also instigates a metabolic shift in steroid synthesis from estradiol predominance to progesterone dominance, concomitant with heightened OXPHOS-centered metabolism [71, 72]

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After surface modification, the hydrodynamic diameter of the TP-10@CaP-CTP nanoparticles was approximately 140 nm, which was larger than that of the TP-10@CaP (92.9 nm) and TP-10@CaP-DSPE-PEG (125.6 nm) nanoparticles, as indicated by dynamic light scattering (DLS) measurements (Fig