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Overman MJ, Morris V, Kee B, Fogelman D, Xiao L, Eng C, Dasari A, Shroff R, Mazard T, Shaw K, Vilar E, Raghav K, Shureiqi I, Liang L, Mills GB, Wolff RA, Hamilton S, Meric-Bernstam F, Abbruzzese J, Morris J, Maru D, Kopetz S
Our study demonstrates that the UPR sensor protein IRE1 is a critical factor in determining cellular sensitivity to ferroptosis through regulating GSH availability (Fig
Para to ortho repositioning of the arsenical moiety of the angiogenesis inhibitor 4-( N -( S -glutathionylacetyl)amino)phenylarsenoxide results in a markedly increased cellular accumulation and antiproliferative activity