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Following administration of rapamycin, all four treated dogs (#2, 3, 4, and 6) had measurable rapamycin blood concentrations that were detectable by HPLC/MS/MS (Table 2)

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Illustration by Karley Koenig

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The bioavailability and efficacy of these compounds depend on their source, metabolism, route of administration, and delivery strategies, with nanotechnology representing an innovative approach to optimizing cellular targeting