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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

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According to the THPdb database published in PLOS ONE, the FDA has approved hundreds of peptide and peptide-protein therapeutics to date

This section is structured to present a logical progression from therapeutic strategies and their enabling tools to the advanced delivery technologies required for their success