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For practical comparison: | Property | Native IGF-1 | IGF-1 DES | IGF-1 LR3 | |---|---|---|---| | Amino acids | 70 | 67 | 83 | | Half-life | ~10 min | ~20-30 min | ~20-30 h | | IGFBP-3 affinity | High | Low | Very low (~1,000x reduced) | | Relative IGF-1R potency | 1x | ~10x | ~2-3x | | Systemic vs

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[DOI] [PubMed] [Google Scholar] 227.Melese E., Asres K., Asad M., Engidawork E

Some practitioners are very skilled in helping patients deal with these hinderances

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