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Supporting this concept, total glutathione concentration appears to declines with aging, as demonstrated in both rat models of aging and in human aging (particularly after age 45 in humans), possibly due to a reduced ability to synthesize GSH

They are a rich source of soluble factors such as ROS, peptides, cytokines and enzymes that exert antimicrobial activities [257]

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This efficacy limitation, rather than safety concerns, halted further development