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Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency

Science 332 , 970974 (2011)

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In terms of the capacity for GSH oxidation through GRX-PRXII compared to the ascorbate-glutathione pathway, it is interesting to compare the k cat and k cat / K M values of PRXII and DHAR obtained when the respective oxidants (peroxide and DHA) were varied