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Anything which irritates the mucosal lining of the nose wouldnt be tolerated, congested nasal passages could inhibit delivery, and its not clear how far or where into the brain the substances might reach

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Numerous studies indicated that borneol inhibited P-gp activity and reversibly modulated TJs proteins expression, thereby enhancing drug permeability across the BBB in neural tissue [133, 134]

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It is recommended to test on a small part of the skin before full use