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Real-time PCR arrays reveal upregulation of MMP-2 and MMP-9 transcripts, while zymography assays confirm corresponding increases in enzymatic activity levels within conditioned media samples

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Ophthalmic Indications: When applied topically as a 2.5% or 10% ophthalmic solution, phenylephrine stimulates the iris dilator muscle to produce mydriasis (pupil dilation)

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Other significant factors include genetic variations, nutritional deficiencies of cofactors (copper, zinc, manganese), overwhelming oxidative stress, and inflammatory conditions that alter SOD expression or activity