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In old animals, both high-dose paraxanthine and caffeine significantly reduced escape latency compared to control, while a trend was observed for low-dose paraxanthine

These improvements persisted for at least 2 weeks after treatment cessation, supporting a sustained symptomatic relief and skin barrier-restorative effects

The discussed studies were obtained from databases (PubMed, SciFinder), using the keyword Pycnogenol and placebo or double-blind. 2 Randomized, double-blind placebo-controlled human clinical studies with Pycnogenol The RDP human clinical studies conducted with Pycnogenol are summarized in Table 1, including a brief description of the study details and main findings

Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, et al

No significant effect was reported in measures of functional autonomy, mood, and behavioral disorders