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10.1038/s41591-020-01183-8 Nat Med

They are studied in different ways, so a better answer is not a clean one

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The direct, quantified, longitudinal human measurements that would settle it are largely absent from the published cagrilintide monotherapy literature, and there is a credible mechanistic reason the tendency of long-acting gut-hormone agonists toward gastric-emptying tachyphylaxis, plus obesity-associated amylin-receptor down-regulation to suspect the gastric arm may attenuate even as central satiety persists

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BPC 157 may serve as a novel mediator of Roberts cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect