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Researchers designing combination protocols should treat the combination as an area of active investigation with mechanistic rationale rather than an established protocol with defined clinical outcomes

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Cominetti C, de Bortoli MC, Garrido AB, Cozzolino SMF

The urothelium of the bladder is indeed coated by a thick layer of glycosaminoglycans (GAGs), which acts as a non-specific anti-adherence factor and defense mechanism against infections and irritants