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It has been reported that patients with adenomatous polyps have significantly elevated levels of IGF-2 ( P = 0.0001) [82]

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The medical ethics committee of the Hospital Network Antwerp (ZNA, approval numbers 2805 and 2806) granted the ethical approval and the study was compliant with the World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research Involving Human Subjects

Instead, it appears to reduce their activity through a different mechanism, possibly by converting the active form of these enzymes to an inactive state (Li et al., 2013