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Starting both agents at lower doses than typically used for monotherapy and escalating more slowly can improve tolerability

doi: 10.1021/jo0703092 94 SaedisomeoliaAAshooriM

Always consult your healthcare provider if you have concerns or questions about your treatment

32,33 Thus, due to the complexity of the HIF signaling cascade and intricacies of nephron anatomy, substantial uncertainty remains regarding the impact of available treatments on HIF signaling and whether such alterations are beneficial to patients with DKD

GLP-1 receptor agonists: beyond their pancreatic effects