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Increased oxidative stress induces high ROS levels and diminishes the interaction between KEAP1 and PGAM5, a mitochondrial serinethreonine phosphatase [74, 160]

A value of this kind implies that the PGRMC1 dimer is more stable than other dimers of extracellular domain of membrane proteins such as Toll like receptor 9 (dimerization K d of 20 mol l 1 ) (ref

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