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RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastomaa phase II study

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Oncologist 29(2):e206e212

Warburg effect The high utilization of glycolysis by rapidly proliferating cells and the subsequent release of lactate into the extracellular milieu

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Cells involved in repair (fibroblasts, endothelial cells, muscle cells) appear to respond through signaling changes that support migration, collagen organization, and local tissue rebuilding