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JAK2 activation in BPC-157-treated tendon fibroblasts occurs in a time-dependent manner following growth hormone stimulation, indicating the peptide primes cells for enhanced growth factor responsiveness rather than directly activating the pathway in the absence of the endogenous ligand
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[DOI] [PMC free article] [PubMed] [Google Scholar] 318
The main benefits seen in studies include reduced pain, improved sensation (such as better detection on monofilament tests in people with diabetes), improved nerve signaling in some cases, and reduced swelling in nerves when measured with ultrasound (Effect of Extracorporeal Shockwaves on Diabetic Neuropathic Foot, 2020
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