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In individuals with elevated baseline AST/ALT (non-alcoholic fatty liver, alcohol use, medication-related elevation), clinical studies have documented measurable enzyme normalization in the 4-8 week window

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A conserved dual function of the conserved lysine residue for redox catalysis is also supported by previous studies: Lys19 of human Grx1 and Lys8 of NrdH-redoxin from C

Start with lower doses to assess tolerance and gradually increase over 2-3 weeks