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Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

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Alzheimer's disease was officially listed as the sixthleading cause of death in the United States in 2024 and the fifthleading cause of death among Americans age 65 and older