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A successful alternation was defined as three consecutive entries into three different arms (i.e

an explanation may be that the generation of hydrogen peroxide by the polymorphonuclear neutrophiles might cause a decrease in the quantity of reduced glutathione, whose function is to eliminate, from the red cell, the accumulated metabolites that oxidate the sulfhydryl groups formed by the oxidative stress and therefore decreasing the protective capacity of the cell

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If water isnt enough, add a stool softener like Colace