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Several findings support the hypothesis that the onset of RA is linked to the intestinal microbiota, for example that cell wall fragments from various intestinal bacteria have been found to be arthritogenic 6,7 , some drugs used to treat arthritis have antimicrobial effects (chloroquine, sulfasalazine and minocycline) 8,9,10 and the restoration of eubiosis in arthritis patients showing clinical improvement 7,11
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First, GHKCu(II) has an anti-inflammatory effect by protecting the tissue from oxidative damage and by suppressing local inflammatory signals (i.e
