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Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes

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For example, although nobiletin alleviates AKI in UUO mice by suppressing ferroptosis, it induces ferroptosis in melanoma cells through the GSK3-regulated Keap1/NRF2/HO-1 pathway [248, 306]

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LL-37 (the active form of human cathelicidin antimicrobial peptide) operates within a tightly regulated circadian framework

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Forman and Zhang, 2021)

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10.1016/j.urology.2019.06.041 17

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