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EMEA/H/C/003834 - Summary of the European Public Assessment Report (EPAR) for Raxone
Molecular structures of siRNA are subjected to chemical modifications, such as the addition of 2-O-methyl or 2-fluoro replacements (106), in order to enhance their stability and reduce the occurrence of off-target effects, while simultaneously enhancing transport efficiency and limiting adverse effects
In comparison with the S-1 plus cisplatin treatment, the median overall survival time was 13 months and the median progression-free survival time was 6 months [163]
doi: 10.1101/cshperspect.a040550