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Instead, the authors showed that hyperosmotic shock leads to breakdown of sphingomyelin, accumulation of ceramide, and later on to PS exposure and cell shrinkage

Therefore, TIR is considered an ineffective strategy for addressing DXN-induced cognitive deficits and oxidative stress

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It oxidizes thiol groups of proteases, facilitating enzymatic activation and downstream substrate cleavage, leading to apoptosis [81]

3.2 Hot embossing and injection molding Two alternative ways for slightly lowering the production cost are represented by hot embossing and injection molding

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