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This increase in size is accompanied by a decrease in the total AR binding activity in the penis from 730 fmol/gm tissue in 3-week-old prepubertal rats to less than 50 fmol/gm in 10-weekold rat penis (see Figure, next page)

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Whilst we found that melatonin did not affect the concentration of G6P ( Figure 5H ), it did seem to greatly reduce the amount of F6P present in our cell samples, indicating potentially that the key disruption to this pathway occurred at the step where G6P is converted to F6P ( Figure 5E )

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