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In zebrafish embryos, OTA inhibits the prolactin receptor (PrLRA) and causes brain bleeding by acting on miR-731 (78)

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This perpetuates the inflammatory response by increasing the release of proinflammatory cytokines in microglia cells and astrocytes (211)

The neuroprotective effect of DMSO observed in this study agrees with other studies reported by (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury