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The alkyl radical in the presence of oxygen is converted to peroxyl radicals which facilitate the long-term damage by continually regenerating themselves through hydrogen abstraction from the nearby biomolecules and forming the hydroperoxides as the byproduct (Fig

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Besides, several drugs (e.g., quercetin and safflower yellow) that promote AMPK phosphorylation have been found to delay the progression of OA by reducing chondrocyte apoptosis, inhibiting inflammatory factors (e.g., TNF-, IL-1, and MMP-13), and modulating ER stress (116, 117)

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While complications are relatively mild, the increase in cosmetic procedures has led to an increase in reported complications