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This may point to the receptor for IL-1, IL-1R1, as a viable therapeutic target for reducing BBB damage after ischemic reperfusion injury (Pan et al., 2023)

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The inhibition of PI3K/Akt and ERK1/2 also significantly decreased NAMPT-induced VEGF expression and activation, leading to important inhibition of endothelial cell proliferation and in the formation of new vessels

Bauer M, Herbarth O, Aust G, Hengstler JG, Dotzauer A, Graebsch C, et al

JDCA analysts downloaded all type 1 diabetes trials registered on the clinicaltrials.gov database, reviewed each one, and categorized them by research type (see Appendix A for categories)