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During CSD, an excitatory wave sweeps across the cerebral cortex, altering the cerebral blood supply, enhancing neuronal excitability, and triggering the release of neuroactive peptides

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Impairment of the intestinal barrier facilitates the translocation of bacteria and microbial metabolites, such as IS and LPS, into systemic circulation, inducing endotoxemia ( Figure 2 ) [112]

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A P value of less than 0.05 was considered statistically significant for univariate/1-group analyses