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MS (ESI) m/z:356.14, found 379.13 [M + Na] +

Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-met kinase inhibitors

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The molecule has been altered in two key ways: The Long modification adds 13 amino acids, increasing the peptides half-life to 2030 hours , compared to 1015 minutes for native IGF-1

Perner A, Nielsen SE, Rask-Madsen J

In contrast, severe hypoxemia is a defining feature of ARDS and is thought to be a consequence of loss of alveolar-capillary barrier function