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Vitamin B12 is a water-soluble vitamin that acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, supporting nerve function, red blood cell production, and DNA synthesis

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Endothelial damage can be provoked by a number of mechanisms, such as a change in the surface tension of the plasma membrane or modification of the physicalchemical milieu of the endothelial cell through a change of intravascular pH or osmolality