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It has poor metabolic stability, a short half-life in circulation, and limited bioavailability when administered systemically

[9] For comparison, known interactions with statins, the most common co-medication, include grapefruit juice (CYP3A4 inhibition raises simvastatin AUC by up to 300%) and rifampin (CYP3A4 induction lowers atorvastatin AUC by approximately 80%)

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Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis

121 NINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators (2015)