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In addition, factors affecting oxidative stress, the necessary co-factor in APAP-induced neurological injury (discussed in detail below), may change over time [41]

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Bai L, Yan F, Deng R, Gu R, Zhang X, Bai J (2021) Thioredoxin-1 rescues MPP+/MPTP-induced ferroptosis by increasing glutathione peroxidase 4

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Altogether, these data support the hypothesis that G6PD-d drives ROS accumulation and may thereby amplify proinflammatory signaling or gene transcription in the absence of an acute stimulus 30