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Laboratory research has established FOXO4-DRI as an invaluable tool for investigating fundamental questions in aging biology, regenerative medicine, cancer research, and tissue engineering, with its proven efficacy across diverse experimental models enabling researchers to test causal relationships between senescence and age-related phenotypes

A more recent analysis focused on neuropathy found improvements in pain, some nerve conduction tests, and reduced swelling of nerves

The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

"Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus"

Physiol Rev 83 : 10171066