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Experimental results showed a modulation interaction of DSIP with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine

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doi: 10.3389/fendo.2023.1200391 124

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These include autoimmune conditions, Parkinson's disease, Alzheimer's disease, and cancer

Studies have shown that HK2 is upregulated in various tumors, promoting cancer cell proliferation, invasion, and metastasis ( Phosphofructokinase-1 (PFK-1), another key rate-limiting enzyme of glycolysis, exists in three isoforms including PFKM, PFKL, and PFKP