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This interaction was mapped at the hydrophobic domain of G0S2 and the patatin-like domain of PNPLA2, whereby overexpression of G0S2 diminished adipocyte lipolysis, and deletion increased both basal and stimulated lipolysis (52)

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Studies have demonstrated that Epithalon influences gene expression at the epigenetic level, inducing decondensation of heterochromatin near centromeres in aged lymphocytes and activating previously silenced genes