Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T
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It seems to us, therefore, that it is necessary to carry out an assessment, conducted jointly by a medical doctor and a psychologist, which examines the patients life history, highlighting psychological and biological critical passages
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DSIP is widely studied in peptide neurobiology due to its ability to influence hypothalamic function, monoaminergic pathways, and circadian rhythm regulation
