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Elevating NAD+ while inhibiting its methylation loss through NNMT inhibition may enhance mitochondrial biogenesis and oxidative phosphorylation efficiency

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[5] Topical GHK-Cu is generally considered well tolerated, yet therapy should be avoided in individuals with a known hypersensitivity to copper peptides or any vehicle component

But, whether or not to use them should depend on what each patient needs and what the doctor says