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The study found no significant differences in systemic side effects between routes, but noted that injection site reactions were the leading cause of treatment discontinuation (3% of injectable users versus 1% of oral users discontinuing due to GI upset)

We therefore presume that sensory inputs or other mechanisms not available in the in situ presentation are responsible for the exaggerated effects on Ti as opposed to Te in vivo

These processes are particularly important during surgery or infection when the demand for immune cell production and tissue regeneration increases [31,33]

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