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Berberine reduces lipid accumulation by promoting fatty acid oxidation in renal tubular epithelial cells of the diabetic kidney

Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]

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J Am Coll Nutr 1994;13:559-64

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These patients may also be presenting symptoms of myopathy, retinopathy, optic atrophy, sensorineural hearing loss, and hypertrophic cardiomyopathy