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Several fungi inhabiting the woody tissues were shown to be causal agents of the esca disease complex (Bertsch et al., GSTs and the ratio of GSSG to total glutathione were suggested as early indicators of the presence of the esca disease in grapevine canes (Valtaud et al., Regulation of GST Genes During Plant-Fungus Interactions Limited information is available about the regulation of plant GSTs during fungal infections

WT) or 50 mg/kg tamoxifen for 5 days (KO)

Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs

Oral citicoline (four cycles of 500 mg/day for four months followed by a two-month washout period) was also found to significantly reduce the rate of visual field loss and the level of intraocular pressure in 41 patients with progressive glaucoma (89)

However, the evaluation of the prognostic value of IGF-1 serum concentrations as a continuous measure by using restricted cubic splines revealed a nonlinear association with reduced mortality for high IGF-1 levels (p-value 0.01, Fig