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Alterations in grapevine leaf metabolism occur prior to esca apoplexy appearance

Lack of response to laser comb in spontaneous and graft-induced alopecia areata in C3H/HeJ mice

Through a series of enzyme-driven reactions, Phase 1 alters the structure of toxins via: Oxidation introducing oxygen to increase chemical reactivity Reduction removing oxygen to alter molecular configuration Hydrolysis breaking chemical bonds using water Hydration adding water molecules to facilitate further processing Dehalogenation removing halogen atoms such as chlorine or bromine The purpose of Phase 1 is not elimination, but activation

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Ioannides, Isothiocyanates and Xenobiotic Detoxification, Mol