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Behavioral Testing

Abbreviations A: Amyloid-beta AD: Alzheimers disease AF: Atrial fibrillation AMPK: AMP-activated protein kinase ATP: Adenosine triphosphate BBB: Bloodbrain barrier CAD: Coronary artery disease CAA: Cerebral amyloid angiopathy CVDs: Cardiovascular diseases DMF: Dimethyl fumarate ETC: Electron transport chain HF: Heart failure IMM: Inner mitochondrial membrane IMS: Intermembrane space IR: Insulin resistance I/R: Ischemiareperfusion LVH: Left ventricular hypertrophy MAPK: Mitogen-activated protein kinase MitoQ: Mitochondria-targeted coenzyme Q10 mPTP: Mitochondrial permeability transition pore mTOR: Mammalian target of rapamycin mtDNA: Mitochondrial DNA NAD: Nicotinamide adenine dinucleotide NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NO: Nitric oxide Nrf2: Nuclear factor erythroid 2-related factor 2 OMM: Outer mitochondrial membrane OXPHOS: Oxidative phosphorylation PGC-1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ROS: Reactive oxygen species SGLT2: Sodium-glucose cotransporter 2 SOD2: Superoxide dismutase 2 TGF-: Transforming growth factor-beta T2D: Type 2 diabetes ULK1: Unc-51 like autophagy activating kinase 1 VaD: Vascular dementia VCI: Vascular cognitive impairment VSMCs: Vascular smooth muscle cells eNOS: Endothelial nitric oxide synthase References Zhu XY, Shi MQ, Jiang ZM, et al

Monitor Responses Track recovery progress and watch for any side effects

Hypothalamic Pathway The hypothalamus regulates GHRH and somatostatin secretion, which determine the timing of GH pulses

Psychiatry 19, 259264

Encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles using the emulsion-evaporation method PLGA (30 mg) was dissolved in chloroform containing DDA-GSH-AuNCs (1.5 mL), and then emulsified into aqueous PVA solution (2.5% w/w, 5.0 mL) using sonication for 60 s (ultra-probe sonicator at 50 W, UP200Ht, Hielscher Ultrasonics, Teltow, Germany)